Emerging perspectives in prostate cancer: Insights from the 4th Asia Pacific Prostate Cancer Conference☆
نویسندگان
چکیده
Prostate cancer is the main cause of cancer-related mortality among men. And although surgery and radiation have been successful treatments, between 30% and 40% of prostate cancer patients progress to advanced forms of the disease.1 Almost all patients with metastatic prostate cancer go on to develop castration-resistant prostate cancer (CRPC).2 From2004 to 2010, docetaxel-based chemotherapywas the only approved agent for the treatment of metastatic CRPC.3,4 Nevertheless, significant advances in the understanding of the androgen pathway role over the last decade have led to the development of alternative novel hormonal agents such as abiraterone and enzalutamide to treat advanced castration-resistant prostate cancer. Both agents target the androgen axis but with distinct mechanisms of action. Abiraterone inhibits the synthesis of androgen by blocking cytochrome P450 17, while enzalutamide inhibits the androgen
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2015